About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Jag1tm1.1Vtlr
targeted mutation 1.1, Verdon Taylor
MGI:3612395
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Jag1tm1.1Vtlr/Jag1+
Notch1tm2Agt/Notch1+ 		involves: 129 MGI:3618372


Genotype
MGI:3618372
cx1
Allelic
Composition		 Jag1tm1.1Vtlr/Jag1+
Notch1tm2Agt/Notch1+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1.1Vtlr mutation (0 available); any Jag1 mutation (76 available)
Notch1tm2Agt mutation (0 available); any Notch1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:103728 )
• most double heterozygotes die a few hours after birth; only 10% survive up to 8 days

nervous system
abnormal rostral migratory stream morphology ( J:103728 )
• at P4, there is a significant reduction in the number of mitotic cells in the rostral migratory stream of brains from mutants at P4
abnormal postnatal subventricular zone morphology ( J:103728 )
• at P4, there is a significant reduction in the number of dividing cells in the subventricular zone of brains from double heterozygotes
• at P8, the subventricular zone is noticeably thinner, with reduced cellularity and a 60% reduction in the number of proliferating cells compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory