Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Lfp mutation
(0 available);
any
Ntrk2 mutation
(66 available)
|
|
|
nervous system
|
|
• delay in barrel formation through P6, but the deficiency disappears by P8
|
|
|
• innervation into layer IV of the cortex by thalamic axons is uniform (rather than segregated into individual barrels) and exhibits a reduced branching within this layer compared to controls at P6, but becomes less apparent by P8
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Lfp mutation
(0 available);
any
Ntrk2 mutation
(66 available)
|
|
|
mortality/aging
|
|
• average lifespan is 3.39 days (10 of 28 die within the first day), however those that survive past 5 days, die at an average age of 10.8 days and the maximum life span is 15 days
|
nervous system
|
|
• severe loss of radial fibers in the apical region of the cochlea, but less severe than in homozygous Ntrk2tm1Bbd mice in the middle and basal turns of the cochlea
|
|
|
• 12% reduction of neuron number in cochlear ganglia
|
|
|
• 94% reduction of neuron number in geniculate ganglia
|
|
|
• 56% reduction of neuron number in nodose/petrosal ganglia
|
|
|
• 22% reduction of neuron number in trigeminal ganglia
|
|
|
• 56% reduction of neuron number in nodose/petrosal ganglia
|
|
|
• 74% reduction of neuron number in vestibular ganglia
|
Analysis Tools