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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P2ry4tm1Brob
targeted mutation 1, Bernard Robaye
MGI:3612162
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		\P2ry4tm1Brob/\P2ry4tm1Brob involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3620219
ot2
 		\P2ry4tm1Brob/Y involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3620220


Genotype
MGI:3620219
hm1
Allelic
Composition		 \P2ry4tm1Brob/\P2ry4tm1Brob
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry4tm1Brob mutation (0 available); any P2ry4 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:103975 )
• fewer than expected newborn female homozygotes are found; however the expected number of newborn hemizygous males are seen

digestive/alimentary system
abnormal digestive secretion ( J:103975 )
• the jejunal chloride secretory response to UTP and ATP is absent




Genotype
MGI:3620220
ot2
Allelic
Composition		 \P2ry4tm1Brob/Y
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry4tm1Brob mutation (0 available); any P2ry4 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive secretion ( J:103975 )
• the jejunal chloride secretory response to UTP and ATP is absent




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory