Phenotypes associated with this allele

• Allele Symbol: Cartpt^tm1Amgn
• Allele Name: targeted mutation 1, Amgen
• Allele ID: MGI:3612125
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cartpt^tm1Amgn/Cartpt^tm1Amgn	involves: 129X1/SvJ * Black Swiss	MGI:3612951

Genotype
MGI:3612951

hm1

• Allelic Composition: Cartpt^tm1Amgn/Cartpt^tm1Amgn
• Genetic Background: involves: 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:103911 )

• about 14% increase in body weight at 40, but not 12 and 20, weeks of age, without any differences in food intake

homeostasis/metabolism

decreased insulin secretion ( J:103911 )

• impaired glucose-stimulated insulin secretion both in vivo after intravenous glucose challenge and in vitro following incubation of isolated islets in the presence of glucose, both at 8 and 40 weeks of age

increased circulating insulin level ( J:103911 )

• higher basal blood insulin levels at 40 weeks of age but not at 8 weeks of age

impaired glucose tolerance ( J:103911 )

• glucose elimination after intravenous glucose challenge is impaired at 8 and 40 weeks of age

endocrine/exocrine glands

decreased insulin secretion ( J:103911 )

• impaired glucose-stimulated insulin secretion both in vivo after intravenous glucose challenge and in vitro following incubation of isolated islets in the presence of glucose, both at 8 and 40 weeks of age