Phenotypes associated with this allele

• Allele Symbol: Ptprc^loc
• Allele Name: lochy
• Allele ID: MGI:3611894
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprc^loc/Ptprc^loc	C57BL/6JSfdAnu-Ptprc^loc/AnuApb	MGI:3615339

Genotype
MGI:3615339

hm1

• Allelic Composition: Ptprc^loc/Ptprc^loc
• Genetic Background: C57BL/6JSfdAnu-Ptprc^loc/AnuApb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal thymocyte activation ( J:104190 )

• TCRbeta^hi and CD69⁺ T cells are diminished in mutant thymi, implying a defect in the TCR signaling necessary for positive selection

abnormal B cell number ( J:104190 )

• although homozygous mutant mice have normal overall numbers of B cells and of bone marrow B220⁺CD19⁺ cells, their bone marrow contains reduced numbers of B220^loCD19⁺ cells

• numbers of IgM⁺IgD^-, IgM⁺IgD⁺ and IgD⁺CD21(CR2)⁺ B cells in mutant bone marrow are slightly diminished

abnormal T cell morphology ( J:104190 )

• expression of co-receptors on homozygous mutant SP T cells is 1.5-fold higher than on SP T cells of control mice

abnormal T cell selection ( J:104190 )

abnormal double-positive T cell morphology ( J:104190 )

• DP thymocytes of mutant mice have 2.5-fold higher expression of CD4 and CD8 on their surfaces than do those of controls

• CD5 is down-regulated on DP thymocytes and up-regulated on peripheral T cells of mutant mice

• TCRbeta is elevated on DP thymocytes and down-regulated on mature T cells of mutant mice

arrested T cell differentiation ( J:104190 )

• mutant thymocytes are blocked in their maturation from DP to SP T cells; this is atributed to a defect in thymic selection

abnormal memory T cell number ( J:104190 )

• in mutant mice, there is a reduction in the proportion of naive CD8⁺ T cells and a shift toward an activated/memory CD8⁺ T cell phenotype

decreased T cell number ( J:104190 )

• peripheral T cell numbers of mutant mice are reduced

decreased double-positive T cell number ( J:104190 )

• thymi of homozygous mutant mice contain 3-fold fewer CD4⁺ CD8⁺ (DP) thymocytes than those of controls

decreased CD4-positive, alpha-beta T cell number ( J:104190 )

• thymi of homozygous mutant mice contain 10-fold fewer SP CD4⁺ CD8^- thymocytes than those of controls

decreased CD8-positive, alpha-beta T cell number ( J:104190 )

• thymi of homozygous mutant mice contain 5-fold fewer SP CD4^- CD8⁺ cells than those of controls

• homozygous mutant mice have a dramatic reduction in CD8⁺ CD44^lo T cell numbers

immune system

abnormal thymocyte activation ( J:104190 )

• TCRbeta^hi and CD69⁺ T cells are diminished in mutant thymi, implying a defect in the TCR signaling necessary for positive selection

abnormal B cell number ( J:104190 )

• although homozygous mutant mice have normal overall numbers of B cells and of bone marrow B220⁺CD19⁺ cells, their bone marrow contains reduced numbers of B220^loCD19⁺ cells

• numbers of IgM⁺IgD^-, IgM⁺IgD⁺ and IgD⁺CD21(CR2)⁺ B cells in mutant bone marrow are slightly diminished

abnormal T cell morphology ( J:104190 )

• expression of co-receptors on homozygous mutant SP T cells is 1.5-fold higher than on SP T cells of control mice

abnormal T cell selection ( J:104190 )

abnormal double-positive T cell morphology ( J:104190 )

• DP thymocytes of mutant mice have 2.5-fold higher expression of CD4 and CD8 on their surfaces than do those of controls

• CD5 is down-regulated on DP thymocytes and up-regulated on peripheral T cells of mutant mice

• TCRbeta is elevated on DP thymocytes and down-regulated on mature T cells of mutant mice

arrested T cell differentiation ( J:104190 )

• mutant thymocytes are blocked in their maturation from DP to SP T cells; this is atributed to a defect in thymic selection

abnormal memory T cell number ( J:104190 )

• in mutant mice, there is a reduction in the proportion of naive CD8⁺ T cells and a shift toward an activated/memory CD8⁺ T cell phenotype

decreased T cell number ( J:104190 )

• peripheral T cell numbers of mutant mice are reduced

decreased double-positive T cell number ( J:104190 )

• thymi of homozygous mutant mice contain 3-fold fewer CD4⁺ CD8⁺ (DP) thymocytes than those of controls

decreased CD4-positive, alpha-beta T cell number ( J:104190 )

• thymi of homozygous mutant mice contain 10-fold fewer SP CD4⁺ CD8^- thymocytes than those of controls

decreased CD8-positive, alpha-beta T cell number ( J:104190 )

• thymi of homozygous mutant mice contain 5-fold fewer SP CD4^- CD8⁺ cells than those of controls

• homozygous mutant mice have a dramatic reduction in CD8⁺ CD44^lo T cell numbers

endocrine/exocrine glands

abnormal thymocyte activation ( J:104190 )

• TCRbeta^hi and CD69⁺ T cells are diminished in mutant thymi, implying a defect in the TCR signaling necessary for positive selection