Phenotypes associated with this allele

• Allele Symbol: Trp53^bhy
• Allele Name: B-thy
• Allele ID: MGI:3611889
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^bhy/Trp53^bhy	C57BL/6JSfdAnu-Trp53^bhy/Anu	MGI:3611921
ht2	Trp53^bhy/Trp53^+	C57BL/6JSfdAnu-Trp53^bhy/Anu	MGI:3611923

Genotype
MGI:3611921

hm1

• Allelic Composition: Trp53^bhy/Trp53^bhy
• Genetic Background: C57BL/6JSfdAnu-Trp53^bhy/Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:104190 )

• homozygous mutant mice may experience sudden death

neoplasm

increased leukemia incidence ( J:104190 )

• homozygous mutant mice develop primitive hematopoietic or T cell leukemia

cardiovascular system

hemorrhage ( J:104190 )

• homozygous mutant mice have a tendency to hemorrhage, which may result in death

Genotype
MGI:3611923

ht2

• Allelic Composition: Trp53^bhy/Trp53⁺
• Genetic Background: C57BL/6JSfdAnu-Trp53^bhy/Anu

neoplasm

increased tumor incidence ( J:104190 )

• mice heterozygous for this mutation develop tumors of various types

increased lymphoma incidence ( J:104190 )

• multinodal lymphoma

increased T cell derived lymphoma incidence ( J:104190 )

increased teratocarcinoma incidence ( J:104190 )

• teratocarcinoma

increased fibrosarcoma incidence ( J:104190 )

increased hemangiosarcoma incidence ( J:104190 )

increased osteosarcoma incidence ( J:104190 )

increased brain tumor incidence ( J:104190 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:104190 )

nervous system

increased brain tumor incidence ( J:104190 )

skeleton

increased osteosarcoma incidence ( J:104190 )

immune system

increased T cell derived lymphoma incidence ( J:104190 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:104190 )