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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnk3tm1Sgb
targeted mutation 1, Stephen G Brickley
MGI:3611768
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnk3tm1Sgb/Kcnk3tm1Sgb involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3620461
cx2
 		Kcnk3tm1Sgb/Kcnk3tm1Sgb
Kcnk9tm1.1Fles/Kcnk9tm1.1Fles 		B6.Cg-Kcnk3tm1Sgb Kcnk9tm1.1Fles MGI:3836807
cx3
 		Dkk3tm1Cni/Dkk3tm1Cni
Kcnk3tm1Sgb/Kcnk3tm1Sgb 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5444118


Genotype
MGI:3620461
hm1
Allelic
Composition		 Kcnk3tm1Sgb/Kcnk3tm1Sgb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk3tm1Sgb mutation (1 available); any Kcnk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal motor coordination/balance ( J:103747 )
• delayed mastering of balance on accelerating rotarod assay
• more frequent falls in narrow beam-walking test

homeostasis/metabolism
increased circulating aldosterone level ( J:188335 )
• females, but not males, have severely increased plasma aldosterone levels under basal conditions
• potassium-rich diet does not further increase plasma aldosterone levels




Genotype
MGI:3836807
cx2
Allelic
Composition		 Kcnk3tm1Sgb/Kcnk3tm1Sgb
Kcnk9tm1.1Fles/Kcnk9tm1.1Fles
Genetic
Background		 B6.Cg-Kcnk3tm1Sgb Kcnk9tm1.1Fles
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk3tm1Sgb mutation (1 available); any Kcnk3 mutation (34 available)
Kcnk9tm1.1Fles mutation (0 available); any Kcnk9 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145944 )
N
• mice exhibit normal hyperpolarization of hypothalamic neurons in response to glucose




Genotype
MGI:5444118
cx3
Allelic
Composition		 Dkk3tm1Cni/Dkk3tm1Cni
Kcnk3tm1Sgb/Kcnk3tm1Sgb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk3tm1Cni mutation (1 available); any Dkk3 mutation (28 available)
Kcnk3tm1Sgb mutation (1 available); any Kcnk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating aldosterone level ( J:188335 )
• females and males have severely increased plasma aldosterone levels under basal conditions
• potassium-rich diet does not further increase plasma aldosterone levels




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory