Phenotypes associated with this allele

• Allele Symbol: Trp53^Bbl
• Allele Name: b-blast
• Allele ID: MGI:3611496
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^Bbl/Trp53^Bbl	C57BL/6JSfdAnu-Trp53^Bbl/Anu	MGI:3611544
ht2	Trp53^Bbl/Trp53^+	C57BL/6JSfdAnu-Trp53^Bbl/Anu	MGI:3611545

Genotype
MGI:3611544

hm1

• Allelic Composition: Trp53^Bbl/Trp53^Bbl
• Genetic Background: C57BL/6JSfdAnu-Trp53^Bbl/Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:104190 )

• mice homozygous for this mutation develop B-cell leukemia/lymphoma or primitive hematopoietic leukemia at 4-6 months of age

increased B cell derived lymphoma incidence ( J:104190 )

• homozygous mutant mice develop B-cell leukemia, B-cell lymphoma or primitive hematopoietic leukemia at 4-6 months of age

Genotype
MGI:3611545

ht2

• Allelic Composition: Trp53^Bbl/Trp53⁺
• Genetic Background: C57BL/6JSfdAnu-Trp53^Bbl/Anu

neoplasm

increased tumor incidence ( J:104190 )

• between 8 and 15 months of age, mice heterozygous for this mutation develop a variety of solid tumors

increased lymphoma incidence ( J:104190 )

increased T cell derived lymphoma incidence ( J:104190 )

increased fibrosarcoma incidence ( J:104190 )

increased hemangiosarcoma incidence ( J:104190 )

increased osteosarcoma incidence ( J:104190 )

increased teratoma incidence ( J:104190 )

increased brain tumor incidence ( J:104190 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:104190 )

nervous system

increased brain tumor incidence ( J:104190 )

skeleton

increased osteosarcoma incidence ( J:104190 )