All Phenotypes Gria3<tm1.1Rsp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gria3^tm1.1Rsp
targeted mutation 1.1, Rolf Sprengel
MGI:3611329

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Gria3^tm1.1Rsp/Y	B6.129-Gria3^tm1.1Rsp	MGI:3713773

Allelic Composition	Gria3^tm1.1Rsp/Y
Genetic Background	B6.129-Gria3^tm1.1Rsp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3^tm1.1Rsp mutation (0 available); any Gria3 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased alcohol consumption ( J:104146 )

• in two paradigms tested, male knockouts exhibited reduced alcohol-seeking behavior after active extinction and reduced alcohol-self administration after a deprivation period compared to wild-type controls

impaired coordination ( J:104146 )

• knockouts display poorer performance in rotarod and balance beam tests

abnormal locomotor activation ( J:104146 )

• mice show a slight reduction in locomotor activity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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