All Phenotypes Efs<tm1Kale> MGI Mouse

increased immunoglobulin level ( J:103757 )

• significant increase in IgA levels in response to NP-KLH immunization, 3 fold increase in IgA levels in unimmunized mice and an increase in the levels of IL-4 and TGF beta/IL-5 dependent IgA isotype

increased IgG level ( J:103757 )

• significant increase in total IgG and IgG1 levels in response to NP-KLH immunization and an increase in the levels of IL-4 and TGF beta/IL-5 dependent IgG1 isotype

abnormal T cell physiology ( J:103757 )

• T cells exhibit enhanced immune responses

increased interferon-gamma secretion ( J:103757 )

• increase in production of IFN-gamma by T cells in response to TCR stimulation

abnormal interleukin secretion ( J:103757 )

• increase in production of IL-2, IL-4, and IL-5 by T cells in response to TCR stimulation

increased inflammatory response ( J:103757 )

• exhibit enhanced effector immune response, however T and B cell development is normal

small intestinal inflammation ( J:103757 )

• duodenum/proximal jejunum exhibits crypt hyperplasia, marked lymphocytic infiltration of the lamina propria, and moderate to severe villus destruction

• 60% exhibit ileum inflammation and display expansion of the lamina propria, crypt enlargement, and altered epithelial cell morphology or damage

• inflammatory infiltrates consist of T and plasma B cells

liver inflammation ( J:103757 )

• 70% exhibit inflammatory infiltrates in the liver consisting of infiltrates present around hepatic vessels and granulomas arising as multiple foci within the parenchyma

kidney inflammation ( J:103757 )

lung inflammation ( J:103757 )

• lung is less affected than intestine, kidney, or liver