Analysis Tools
normal phenotype
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• homozygotes are viable and fertile and do not exhibit any apparent abnormalities
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Allele Symbol Allele Name Allele ID |
Snx1tm1Mag targeted mutation 1, Terry Magnuson MGI:3610409 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are viable and fertile and do not exhibit any apparent abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos typically arrest and die between E9.5 and E11.5
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• embryos are retarded in growth by E7.5
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• in most cases, do not undergo axial rotation
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• exhibit a truncated posterior at E9.5
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• embryos typically arrest between E9.5 and E11.5
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• embryos are retarded in growth by E7.5
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• neural folds are not fused at E9.5
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• by E8.5, exhibit disproportionate growth of the extraembryonic structures compared with embryonic ectoderm, resulting in a large yolk sac and allantois compared to embryo size
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• overgrowth of the yolk sac is seen at E8.5
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• exhibit an increased prevalence of apical electron dense structures in the yolk sac visceral endoderm
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• variability in chorioallantoic fusion
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• neural folds are not fused at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 40% do not survive development
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• embryos are smaller and growth retarded by E11.5
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• embryos are smaller by E11.5
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• those that survive development are born runted (about 20% smaller) due to developmental growth retardation, with small size continuing into adulthood
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• embryos are smaller and growth retarded by E11.5
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• embryos are smaller by E11.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mutants are born in expected Mendelian ratios
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| N |
• no differences in weight from single homozygous Snx1 mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit no embryonic lethality; born in expected Mendelian ratios
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• second wave of lethality is around E13.5
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• first wave of lethality is around E8.5
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• 100% die during development
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• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5
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• embryos that die around E13.5, exhibit exencephaly
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• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit no lethality; born in expected Mendelian ratios
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• second wave of lethality is around E13.5 in 40% of embryos
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• first wave of lethality is around E8.5
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• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5
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• embryos that die around E13.5, exhibit exencephaly
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• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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