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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vps26atm1Cos
targeted mutation 1, Frank Costantini
MGI:3610386
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Snx2tm1Mag/Snx2tm1Mag
Vps26atm1Cos/Vps26a+ 		involves: 129S/SvEv MGI:3639304
cx2
 		Snx1tm1Mag/Snx1tm1Mag
Vps26atm1Cos/Vps26a+ 		involves: 129S/SvEv MGI:3639307
cx3
 		Snx1tm1Mag/Snx1+
Snx2tm1Mag/Snx2tm1Mag
Vps26atm1Cos/Vps26a+ 		involves: 129S/SvEv MGI:3639310
cx4
 		Snx1tm1Mag/Snx1tm1Mag
Snx2tm1Mag/Snx2+
Vps26atm1Cos/Vps26a+ 		involves: 129S/SvEv MGI:3639313


Genotype
MGI:3639304
cx1
Allelic
Composition		 Snx2tm1Mag/Snx2tm1Mag
Vps26atm1Cos/Vps26a+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx2tm1Mag mutation (1 available); any Snx2 mutation (41 available)
Vps26atm1Cos mutation (1 available); any Vps26a mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:102476 )
• 90% die during development with live embryos recovered as late as E18.5; the 10% that survive do not exhibit hemorrhage or exencephaly and are viable and fertile

cardiovascular system
hemorrhage ( J:102476 )
• embryos at E18.5 exhibit hemorrhage at different sites; occasionally seen in the head with accompanying exencephaly whereas others show blood in the abdomen

nervous system
exencephaly ( J:102476 )
• seen occasionally at E18.5

craniofacial
abnormal craniofacial morphology ( J:102476 )
• craniofacial abnormalities




Genotype
MGI:3639307
cx2
Allelic
Composition		 Snx1tm1Mag/Snx1tm1Mag
Vps26atm1Cos/Vps26a+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx1tm1Mag mutation (1 available); any Snx1 mutation (23 available)
Vps26atm1Cos mutation (1 available); any Vps26a mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:102476 )
• exhibit no embryonic lethality; born in expected Mendelian ratios




Genotype
MGI:3639310
cx3
Allelic
Composition		 Snx1tm1Mag/Snx1+
Snx2tm1Mag/Snx2tm1Mag
Vps26atm1Cos/Vps26a+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx1tm1Mag mutation (1 available); any Snx1 mutation (23 available)
Snx2tm1Mag mutation (1 available); any Snx2 mutation (41 available)
Vps26atm1Cos mutation (1 available); any Vps26a mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:102476 )
• second wave of lethality is around E13.5
prenatal lethality, complete penetrance ( J:102476 )
• 100% die during development

growth/size/body
embryonic growth retardation ( J:102476 )
• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5

nervous system
exencephaly ( J:102476 )
• embryos that die around E13.5, exhibit exencephaly

embryo
embryonic growth retardation ( J:102476 )
• embryos that die by E8.5 are underdeveloped and undergo developmental delay beginning at E7.5




Genotype
MGI:3639313
cx4
Allelic
Composition		 Snx1tm1Mag/Snx1tm1Mag
Snx2tm1Mag/Snx2+
Vps26atm1Cos/Vps26a+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx1tm1Mag mutation (1 available); any Snx1 mutation (23 available)
Snx2tm1Mag mutation (1 available); any Snx2 mutation (41 available)
Vps26atm1Cos mutation (1 available); any Vps26a mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:102476 )
• exhibit no lethality; born in expected Mendelian ratios




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory