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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr1i2tm1Sakl
targeted mutation 1, Steven A Kliewer
MGI:3609633
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nr1i2tm1Sakl/Nr1i2tm1Sakl involves: 129S1/Sv * 129X1/SvJ MGI:4437968
hm2
 		Nr1i2tm1Sakl/Nr1i2tm1Sakl involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3611180


Genotype
MGI:4437968
hm1
Allelic
Composition		 Nr1i2tm1Sakl/Nr1i2tm1Sakl
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2tm1Sakl mutation (3 available); any Nr1i2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased hepatocyte proliferation ( J:157882 )
• in non-pregnant mice

cellular
decreased hepatocyte proliferation ( J:157882 )
• in non-pregnant mice




Genotype
MGI:3611180
hm2
Allelic
Composition		 Nr1i2tm1Sakl/Nr1i2tm1Sakl
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2tm1Sakl mutation (3 available); any Nr1i2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased liver enzyme/coenzyme level ( J:103505 )
• basal levels of Cyp7a1 mRNA are decreased about 2-fold in liver
increased liver enzyme/coenzyme level ( J:103505 )
• basal levels of Cyp3a11 mRNA are increased about 4-fold in liver
abnormal physiological response to xenobiotic ( J:103505 )
• treatment with pregnenolone-16alpha-carbonitrile (PCN) fails to induce Cyp3a11 and Slco1a4 or repress Cyp7a1 expression, unlike in wild-type mice
• treatment with PCN fails to protect homozygotes from lithocholic acid-induced hepatotoxicity
decreased physiological sensitivity to xenobiotic ( J:103235 )
• homozygotes do not develop PCN-induced hepatomegaly

behavior/neurological
impaired behavioral response to xenobiotic ( J:103505 )
• homozygotes are paralyzed for a shorter time (6 min) after zoxazolamine treatment compared to wild-type mice (26 min); however, PCN-treatment has no effect on the length of time mutants are paralyzed unlike in wild-type mice where PCN treatment decreases paralysis time to 2 min

liver/biliary system
decreased liver enzyme/coenzyme level ( J:103505 )
• basal levels of Cyp7a1 mRNA are decreased about 2-fold in liver
increased liver enzyme/coenzyme level ( J:103505 )
• basal levels of Cyp3a11 mRNA are increased about 4-fold in liver




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory