Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Tfjt mutation
(0 available);
any
Adm mutation
(13 available)
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Allelic
Composition |
Admtm1Tfjt/Adm+
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Genetic
Background |
involves: C57BL/6 * CBA |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Tfjt mutation
(0 available);
any
Adm mutation
(13 available)
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cardiovascular system
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• in severe cases fibrinoid necrosis is seen in the perivascular area of the coronary artery in heterozygous mice given angiotensin II and fed a high salt diet
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• inflammation of the perivascular area of the coronary artery is more severe in heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice
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cellular
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• elevated urinary excretion of 8-hydroxydeoxyguanosine and isoprostane, elevated expression of Ncf2 and Cybb, and increased 3-nitrotyrosine staining all indicate elevated oxidative stress in the hearts of heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice
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immune system
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• inflammation of the perivascular area of the coronary artery is more severe in heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice
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Analysis Tools