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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ihhtm1Blan
targeted mutation 1, Beate Lanske
MGI:3609381
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ihhtm1Blan/Ihhtm1Blan
Tg(Col2a1-cre)10Amc/0
involves: 129S4/SvJae * C57BL/6 MGI:3620218


Genotype
MGI:3620218
cn1
Allelic
Composition
Ihhtm1Blan/Ihhtm1Blan
Tg(Col2a1-cre)10Amc/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Blan mutation (1 available); any Ihh mutation (22 available)
Tg(Col2a1-cre)10Amc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

skeleton
• synchondrosis of some bones
• synchondrosis
• synchondrosis of some vertebrae
• no organized growth plate is seen instead hypertrophic cells are located in the center of the cartilage surrounded by undifferentiated chondrocytes
• at E16.5 there is about a 50% decrease in proliferation of chondrocytes
• synchondrosis of some bones of the skull base, vertebrae, and sternum
• dysregulation of chondrocyte maturation
• in the long bones
• at E18.5 in the radius mineralization occurs in the center of the cartilage and not associated with a bone collar
• only hypertrophic chondrocytes located in the center of the cartilage show signs of mineralization
• in general mineralization is delayed until E16.5, with severely affected bones showing greater delays
• mineralization of the radius is initiated in the center of the cartilage at E18.5
• at E18.5, dorsal portions of the ribs and distal parts of the long bones show essentially no mineralization
• however, intramembranous bone formation appears normal

limbs/digits/tail
• failure of digit segmentation
• detectable at E14.5

craniofacial
• synchondrosis of some bones





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory