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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elp6+
wild type
MGI:3609326
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Elp6em1(IMPC)J/Elp6+ C57BL/6NJ-Elp6em1(IMPC)J/Mmjax MGI:6731308
ht2
 		Elp6em1Bjw/Elp6+ Not Specified MGI:8275322


Genotype
MGI:6731308
ht1
Allelic
Composition		 Elp6em1(IMPC)J/Elp6+
Genetic
Background		 C57BL/6NJ-Elp6em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elp6em1(IMPC)J mutation (2 available); any Elp6 mutation (31 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

homeostasis/metabolism




Genotype
MGI:8275322
ht2
Allelic
Composition		 Elp6em1Bjw/Elp6+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elp6em1Bjw mutation (0 available); any Elp6 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
limb grasping ( J:360936 )
• hindlimb clasping
increased locomotor activity ( J:360936 )
• increased spontaneous activity

growth/size/body
growth/size/body region phenotype ( J:360936 )
• no microcephaly or developmental delay
slow postnatal weight gain ( J:360936 )
• owing to reduced feeding ability as a result of motor defects

mortality/aging
premature death ( J:360936 )
• death before age 9 months

muscle

nervous system
nervous system phenotype ( J:360936 )
• normal interneurons and myelin in forebrain at age 60 days
• no microcephaly
abnormal hippocampal pyramidal neuron dendrite morphology ( J:360936 )
• shorter length and less branching at age 60 days
• normal dendritic spine density
abnormal excitatory postsynaptic potential ( J:360936 )
• reduced field excitatory postsynaptic potential (fEPSP) after applying high-frequency stimulation (HFS) to trigger long-term potentiation (LTP) at Schaffer collateral to CA1 pyramidal neuron synapse at age 60 days




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory