All Phenotypes Men1<tm1Mmey> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Men1^tm1Mmey
targeted mutation 1, Matthew Meyerson
MGI:3608952

Summary

2 genotypes

Allelic Composition	Men1^tm1Mmey/Men1^tm1Mmey
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1^tm1Mmey mutation (0 available); any Men1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• homozygous mutant embryo do not develop past day 11.5-12.5 postcoitum

Allelic Composition	Men1^tm1Mmey/Men1⁺
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1^tm1Mmey mutation (0 available); any Men1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

• by 7 months of age, heterozygous mice have hyperplastic and enlarged pancreatic islets

• an increase in numbers of insulin + beta cells in mutant

homeostasis/metabolism

hypoglycemia ( J:102494 )

• by 6-7 months of age, heterozygous mice had mild but significant hypoglycemia during random feeding and after overnight fasting

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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