All Phenotypes Ric8a<tm1Aks> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ric8a^tm1Aks
targeted mutation 1, Alar Karis
MGI:3608888

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ric8a^tm1Aks/Ric8a^tm1Aks	B6.129P2-Ric8a^tm1Aks	MGI:3700168
ht2	Ric8a^tm1Aks/Ric8a⁺	B6.129P2-Ric8a^tm1Aks	MGI:3700169
cn3	Ric8a^tm1Aks/Ric8a^tm1.1Zhua Tg(Atoh1-cre/Esr1*)14Fsh/0	involves: 129P2/OlaHsd * FVB/N	MGI:5467517

Allelic Composition	Ric8a^tm1Aks/Ric8a^tm1Aks
Genetic Background	B6.129P2-Ric8a^tm1Aks

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8a^tm1Aks mutation (0 available); any Ric8a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:115754 )

• die in early development during gastrulation

Allelic Composition	Ric8a^tm1Aks/Ric8a⁺
Genetic Background	B6.129P2-Ric8a^tm1Aks

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8a^tm1Aks mutation (0 available); any Ric8a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:115754 )

• performance in the Morris water maze is impaired, with heterozygotes exhibiting a delay in finding the hidden platform during reversal testing

increased anxiety-related response ( J:115754 )

• mice exhibit increased anxiety in light-dark compartment test where they significantly avoid the light compartment

Allelic Composition	Ric8a^tm1Aks/Ric8a^tm1.1Zhua Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8a^tm1.1Zhua mutation (0 available); any Ric8a mutation (29 available)
Ric8a^tm1Aks mutation (0 available); any Ric8a mutation (29 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:191222 )

N	• granule cell precursors are normal in tamoxifen-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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