All Phenotypes Insig1<tm1.1Mbjg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Insig1^tm1.1Mbjg
targeted mutation 1.1, Joseph L Goldstein
MGI:3607577

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Insig1^tm1.1Mbjg/Insig1^tm1.1Mbjg Insig2^tm1Mbjg/Insig2^tm1Mbjg	involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N	MGI:3607698
cx2	Insig1^tm1.1Mbjg/Insig1^tm1.1Mbjg Insig2^tm1Mbjg/Insig2⁺	involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N	MGI:3607699

Allelic Composition	Insig1^tm1.1Mbjg/Insig1^tm1.1Mbjg Insig2^tm1Mbjg/Insig2^tm1Mbjg
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insig1^tm1.1Mbjg mutation (0 available); any Insig1 mutation (15 available)
Insig2^tm1Mbjg mutation (1 available); any Insig2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:101203 )

• observe 82% of the expected double homozygotes at E18.5 and none at genotyping

Allelic Composition	Insig1^tm1.1Mbjg/Insig1^tm1.1Mbjg Insig2^tm1Mbjg/Insig2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:101203 )

• only 3 of 12 expected mice were observed at genotyping

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