All Phenotypes Hrh2<tm1Yfks> MGI Mouse

abnormal gastric gland morphology ( J:102252 )

• enterochromaffin-like (ECL) cells are increased in number and are more widely distributed throughout the gastric mucosa

abnormal gastric chief cell morphology ( J:102252 )

• decrease in the number of mature chief cells

abnormal gastric parietal cell morphology ( J:102252 )

• parietal cells are increased in number, are smaller, and are distributed throughout the entire mucosa

abnormal mucous neck cell morphology ( J:102252 )

• mucous neck cells are increased in number, are distributed deeper in the glands than in wild-type, contain an unusually large amount of mucin and protrude into the gastric gland lumen

gastric gland hyperplasia ( J:102252 )

• hyperplasia of the gastric gland cells

stomach mucosa hyperplasia ( J:102252 )

• mucosal hyperplasia as indicated by the increase in weight of the fundic mucosa

enlarged stomach ( J:102252 )

• stomachs are larger and heavier

decreased digestive secretion ( J:102252 )

• induction of gastric acid secretion by histamine or gastrin is completely abolished

increased stomach pH ( J:102252 )

• basal gastric pH is slightly but significantly higher in fasted mutants and elevation of gastric pH by administration of an Hrh2 antagonist, famotidine, is abolished

increased circulating gastrin level ( J:102252 )

• exhibit hypergastrinemia (increased serum gastrin levels)

• feeding stimuli does not induce an elevation in serum gastrin levels as in wild-type

increased vertical activity ( J:102252 )

• mutants tend to be more active with regards to rearing behavior, however learning and memory appear normal

abnormal seizure response to electrical stimulation ( J:102252 )

• homozygotes are less prone to electrically induced convulsions, but show no differences from wild-type in pentyleneterazole-induced convulsions