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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr174+
wild type
MGI:3606991
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gpr174tm1Cys/Gpr174+ B6.129-Gpr174tm1Cys MGI:5644339
cx2
 		Foxp3tm3(HBEGF/GFP)Ayr/Foxp3+
Gpr174tm1Cys/Gpr174+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5644340


Genotype
MGI:5644339
ht1
Allelic
Composition		 Gpr174tm1Cys/Gpr174+
Genetic
Background		 B6.129-Gpr174tm1Cys
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr174tm1Cys mutation (0 available); any Gpr174 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:222307 )
• MOG-treated mice exhibit a modest reduction in disease compared with wild-type mice




Genotype
MGI:5644340
cx2
Allelic
Composition		 Foxp3tm3(HBEGF/GFP)Ayr/Foxp3+
Gpr174tm1Cys/Gpr174+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm3(HBEGF/GFP)Ayr mutation (2 available); any Foxp3 mutation (57 available)
Gpr174tm1Cys mutation (0 available); any Gpr174 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:222307 )
• in mice treated with diphtheria toxin and MOG




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory