Analysis Tools
mortality/aging
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• homozygous embryos die at E10.5
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embryo
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• at E9.5 a single branchial arch is present unlike wild-type mice which have 3 arches; however, specification and migration of neural crest cells is normal
• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge
• however, in the limb bud patterning of the zone of polarizing activity and the apical ectodermal ridge is normal and the otic vesicle forms normally
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• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge
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• seen at E9.5
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• at E9.5, the labyrinthine region fails to expand correctly reducing the volume of blood spaces
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reproductive system
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• at the headfold stage (E7.75) 2-4 or no primordial germs cells are detected and at E9.0-9.5, no primordial germ cells are detected
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cardiovascular system
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• hemorrhaging with blood pooling in dorsal aorta is observed at E10.5
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hemorrhage
(
J:101718
)
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• at E10.5, severe hemorrhaging is seen with blood pooling in the heart, dorsal aorta and under the surface ectoderm, but at E9.5 development of the heart and blood vessels appears normal
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muscle
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• at E10.5, the Fgf8 domain in the epaxial dermomyotomal lip is expanded
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growth/size/body
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• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge
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• seen at E9.5
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craniofacial
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• at E9.5 a single branchial arch is present unlike wild-type mice which have 3 arches; however, specification and migration of neural crest cells is normal
• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge
• however, in the limb bud patterning of the zone of polarizing activity and the apical ectodermal ridge is normal and the otic vesicle forms normally
|
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• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge
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cellular
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• at the headfold stage (E7.75) 2-4 or no primordial germs cells are detected and at E9.0-9.5, no primordial germ cells are detected
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