Phenotypes associated with this allele

• Allele Symbol: Taf10^tm1.1Lzt
• Allele Name: targeted mutation 1.1, Laszlo Tora
• Allele ID: MGI:3605460
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Taf10^tm1.1Lzt/Taf10^tm1.1Lzt	involves: 129 * C57BL/6 * SJL	MGI:3606187

Genotype
MGI:3606187

hm1

• Allelic Composition: Taf10^tm1.1Lzt/Taf10^tm1.1Lzt
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:101819 )

• die between E3.5 and E6.5

embryo

abnormal inner cell mass apoptosis ( J:101819 )

• blastocysts exhibit an increase in apoptosis, primarily in the inner cell mass

absent inner cell mass proliferation ( J:101819 )

• inner cell mass cells fail to proliferate in culture and die within 2 days of culture

embryonic growth retardation ( J:101819 )

• often developmentally retarded at E4.5

abnormal embryonic tissue morphology ( J:101819 )

• embryos are often completely disorganized by E5.5

abnormal embryonic epiblast morphology ( J:101819 )

• greatly reduced or absent epiblast

absent embryonic epiblast ( J:101819 )

small embryonic epiblast ( J:101819 )

abnormal inner cell mass morphology ( J:101819 )

• inner cell mass size is reduced

abnormal trophoblast layer morphology ( J:101819 )

• trophoblasts stop endocycling and exhibit a reduction in DNA replication and transcription, however saw no differences from wildtype in attachment and spreading in culture

growth/size/body

embryonic growth retardation ( J:101819 )

• often developmentally retarded at E4.5

cellular

abnormal inner cell mass apoptosis ( J:101819 )

• blastocysts exhibit an increase in apoptosis, primarily in the inner cell mass

absent inner cell mass proliferation ( J:101819 )

• inner cell mass cells fail to proliferate in culture and die within 2 days of culture