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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Scn11atm1Dgen
targeted mutation 1, Deltagen
MGI:3604572
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Scn11atm1Dgen/Scn11atm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606607
ht2
Scn11atm1Dgen/Scn11a+ involves: 129P2/OlaHsd * C57BL/6 MGI:3628546


Genotype
MGI:3606607
hm1
Allelic
Composition
Scn11atm1Dgen/Scn11atm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1Dgen mutation (1 available); any Scn11a mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• after treatment with formalin, homozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection), thermal hyperalgesia is less prolonged after treatment with carrageenan or complete Freund's adjuvant and absent after treatment with PGE2
• homozygous mice display length, weight, blood chemistry, fertility, lifespan, and thermal and mechanical nociception similar to wild-type




Genotype
MGI:3628546
ht2
Allelic
Composition
Scn11atm1Dgen/Scn11a+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1Dgen mutation (1 available); any Scn11a mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• after treatment with formalin, heterozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection) and thermal hyperalgesia is less prolonged after treatment with complete Freund's adjuvant





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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory