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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gng7tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3604392
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gng7tm1Lex/Gng7tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609962
cx2
 		Gng3tm1.1Rbs/Gng3tm1.1Rbs
Gng7tm1Lex/Gng7tm1Lex 		B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs MGI:5317909


Genotype
MGI:3609962
hm1
Allelic
Composition		 Gng7tm1Lex/Gng7tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gng7tm1Lex mutation (2 available); any Gng7 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased startle reflex ( J:81988 )
• startle reflex is increased but prepulse inhibition is normal

nervous system
abnormal nervous system physiology ( J:81988 )
• the stimulatory effect of dopamine on adenylyl cyclase activity in the striatum is lost

homeostasis/metabolism
increased circulating insulin level ( J:103485 )
• males exhibit an increased mean insulin level




Genotype
MGI:5317909
cx2
Allelic
Composition		 Gng3tm1.1Rbs/Gng3tm1.1Rbs
Gng7tm1Lex/Gng7tm1Lex
Genetic
Background		 B6.Cg-Gng7tm1Lex Gng3tm1.1Rbs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gng3tm1.1Rbs mutation (0 available); any Gng3 mutation (15 available)
Gng7tm1Lex mutation (2 available); any Gng7 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:182775 )
• 51 of 52 mutants die before 1 year of age, with a median survival of 75 days
• administration of a ketogenic diet prolongs life span of mutants; females on the ketogenic diet have a median survival of 334 days while males have a median survival of 154 days

behavior/neurological
seizures ( J:182775 )
• 19 of 21 mutants experience seizures for about 1 minute immediately prior to death
environmentally induced seizures ( J:182775 )
• 32% of mutants exhibit handling-induced seizures at a median of 18 days before death
tonic-clonic seizures ( J:182775 )
• seizures are characterized by a progression from wild running to tonic-clonic convulsion to tonic hindlimb extension that ends in death

nervous system
seizures ( J:182775 )
• 19 of 21 mutants experience seizures for about 1 minute immediately prior to death
environmentally induced seizures ( J:182775 )
• 32% of mutants exhibit handling-induced seizures at a median of 18 days before death
tonic-clonic seizures ( J:182775 )
• seizures are characterized by a progression from wild running to tonic-clonic convulsion to tonic hindlimb extension that ends in death
abnormal brain delta wave pattern ( J:182775 )
• baclofen, a GABABR-specific agonist, shows impaired ability to induce delta waves on EEG tracings in mutants
abnormal interictal brain wave pattern ( J:182775 )
• mutants exhibit several EEG abnormalities including more interictal discharges and lower interhemispheric coherence compared to wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
epilepsy DOID:1826 J:182775




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory