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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gdf6tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3604391
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gdf6tm1Lex/Gdf6tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609960


Genotype
MGI:3609960
hm1
Allelic
Composition
Gdf6tm1Lex/Gdf6tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf6tm1Lex mutation (2 available); any Gdf6 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• exhibit reduced viability with fewer homozygotes detected at weaning

growth/size/body
• surviving homozygotes exhibit decreased mean body weight, total tissue mass, and lean body mass

skeleton
• exhibit decreased bone-related measurements

nervous system
• exhibit signs of optic disc edema

vision/eye
• exhibit signs of optic disc edema

hearing/vestibular/ear
• exhibit a possible hearing impairment





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory