All Phenotypes Gdf6<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gdf6^tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3604391

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf6^tm1Lex/Gdf6^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609960

Allelic Composition	Gdf6^tm1Lex/Gdf6^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf6^tm1Lex mutation (2 available); any Gdf6 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:103485 )

• exhibit reduced viability with fewer homozygotes detected at weaning

growth/size/body

decreased body weight ( J:103485 )

• surviving homozygotes exhibit decreased mean body weight, total tissue mass, and lean body mass

postnatal growth retardation ( J:103485 )

skeleton

abnormal skeleton morphology ( J:103485 )

• exhibit decreased bone-related measurements

nervous system

abnormal optic disk morphology ( J:103485 )

• exhibit signs of optic disc edema

vision/eye

abnormal optic disk morphology ( J:103485 )

• exhibit signs of optic disc edema

hearing/vestibular/ear

abnormal hearing physiology ( J:103485 )

• exhibit a possible hearing impairment

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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