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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rassf1tm1.1Brd
targeted mutation 1.1 Allan Bradley
MGI:3604204
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rassf1tm1.1Brd/Rassf1tm1.1Brd involves: 129S7/SvEvBrd * C57BL/6 MGI:3715868
cn2
 		Rassf1tm1.1Brd/Rassf1tm1.1Brd
Tg(Myh6-cre)2182Mds/0 		involves: 129S7/SvEvBrd * FVB/N MGI:4837486


Genotype
MGI:3715868
hm1
Allelic
Composition		 Rassf1tm1.1Brd/Rassf1tm1.1Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf1tm1.1Brd mutation (0 available); any Rassf1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:101369 )
• no differences are seen when compared to wild-type mice




Genotype
MGI:4837486
cn2
Allelic
Composition		 Rassf1tm1.1Brd/Rassf1tm1.1Brd
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf1tm1.1Brd mutation (0 available); any Rassf1 mutation (26 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased response of heart to induced stress ( J:165327 )
• following pressure overload hypertrophy, fibrosis and cardiomyocyte apoptosis are decreased and heart function is improved compared to wild-type controls
• in the absence of pressure overload, gross cardiac morphology is similar to controls

homeostasis/metabolism
decreased response of heart to induced stress ( J:165327 )
• following pressure overload hypertrophy, fibrosis and cardiomyocyte apoptosis are decreased and heart function is improved compared to wild-type controls
• in the absence of pressure overload, gross cardiac morphology is similar to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory