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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grm1tm1Kyo
targeted mutation 1, Tadao Serikawa
MGI:3604007
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grm1tm1Kyo/Grm1tm1Kyo involves: C57BL/6 MGI:3608486


Genotype
MGI:3608486
hm1
Allelic
Composition		 Grm1tm1Kyo/Grm1tm1Kyo
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm1tm1Kyo mutation (2 available); any Grm1 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system electrophysiology ( J:101301 )
• low concentration of 3,5-dihydroxyphenylglycine (DHPG, 0.5 and 50 nM) fail to evoke detectable inward currents in homozygous Purkinje cells unlike in wild-type cells, but 500 uM DHPG induces similar inward currents in both homozygous and wild-type cells

behavior/neurological
behavior/neurological phenotype ( J:101301 )
N
• open-field and rotorod test do not detect any behavioral abnormalities




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory