Phenotypes associated with this allele

• Allele Symbol: Tg(Eno2-APPSwe)1223-3Ykk
• Allele Name: transgene insertion 1223-3, Yong K Kim
• Allele ID: MGI:3603946
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Eno2-APPSwe)1223-3Ykk/0	involves: C57BL/6 * DBA/2	MGI:3718109

Genotype
MGI:3718109

tg1

• Allelic Composition: Tg(Eno2-APPSwe)1223-3Ykk/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:100955 )

• after 5 days of training,12-month old transgenic mice show behavioral deficits compared to controls, as escape latencies are longer and swimming distance are significantly greater than controls

• swim velocity is only slightly slower than that of wild-type mice

nervous system

increased neuron apoptosis ( J:100955 )

• in forebrain, number of TUNEL-positive nuclei appears greatert

amyloid beta deposits ( J:100955 )

• brain levels of amyloid (Abeta) are higher than in controls at 12 months of age; Abeta-42 levels are ~3-fold higher

• Abeta deposition is observed in the cortex and hippocampus

loss of hippocampal neurons ( J:100955 )

• at 12 months of age, mice show areas of neuron loss in the hippocampus

cellular

increased neuron apoptosis ( J:100955 )

• in forebrain, number of TUNEL-positive nuclei appears greatert

homeostasis/metabolism

amyloid beta deposits ( J:100955 )

• brain levels of amyloid (Abeta) are higher than in controls at 12 months of age; Abeta-42 levels are ~3-fold higher

• Abeta deposition is observed in the cortex and hippocampus