Phenotypes associated with this allele

• Allele Symbol: Sgk3^tm1Okad
• Allele Name: targeted mutation 1, Hitoshi Okada
• Allele ID: MGI:3603415
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgk3^tm1Okad/Sgk3^tm1Okad	involves: 129P2/OlaHsd	MGI:3607122

Genotype
MGI:3607122

hm1

• Allelic Composition: Sgk3^tm1Okad/Sgk3^tm1Okad
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sgk3^tm1Okad/Sgk3^tm1Okad mice have an abnormal hair coat

cellular

increased hair follicle apoptosis ( J:100992 )

• exhibit an increase in the number of apoptotic cells in P6 follicles, however observe no differences in follicle density

integument

increased hair follicle apoptosis ( J:100992 )

• exhibit an increase in the number of apoptotic cells in P6 follicles, however observe no differences in follicle density

abnormal hair growth ( J:100992 )

short hair ( J:100992 )

• hairs are unusually short, except for guard hairs

sparse hair ( J:100992 )

abnormal hair shaft morphology ( J:100992 )

• hair shafts are malformed, with hair lacking straight segments or organized kinks and instead, curling and bending randomly

abnormal hair cuticle ( J:100992 )

• cuticle cells are poorly adherent to the shaft

abnormal hair medulla ( J:100992 )

• medullated hair shafts are sparse

thin hair shaft ( J:100992 )

• hairs are thin and display thickened knobby regions and thin spindly regions

abnormal hair follicle dermal papilla morphology ( J:100992 )

• dermal papillae remain small and round rather than becoming long and thin

abnormal hair follicle matrix region morphology ( J:100992 )

• the matrix progenitor cell population fails to expand, resulting in reduced numbers of matrix cells

small hair follicle bulb ( J:100992 )

• hair bulbs are smaller, with P6 bulbs the size of P2 bulbs, and fail to grow down to the bottom of the subuctis

kinked vibrissae ( J:100992 )

• whiskers are bent erratically and are often pointed forward or outward

abnormal hair cycle ( J:100992 )

• reduced maintenance or supply of matrix progenitor cells results in impaired maturation of and shorter anagen followed by precocious entry into catagen

accelerated hair follicle regression ( J:100992 )

• follicles prematurely regress, with follicles entering catagen as early as P9 and reentering anagen by P12

decreased hair follicle cell proliferation ( J:100992 )

• exhibit fewer proliferating cells in the hair bulb at P2, resulting in a reduced number of dividing cells at P6