Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-GAD2)2Lt
• Allele Name: transgene insertion 2, Edward H Leiter
• Allele ID: MGI:3603349
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-GAD2)2Lt/0	NOD/ShiLt-Tg(Ins2-GAD2)2Lt	MGI:3618823

Genotype
MGI:3618823

tg1

• Allelic Composition: Tg(Ins2-GAD2)2Lt/0
• Genetic Background: NOD/ShiLt-Tg(Ins2-GAD2)2Lt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:100251 )

• homozygosity for the transgene is developmentally lethal

immune system

insulitis ( J:100251 )

• insulitis develops more slowly in these mice than in the other transgenic GAD transgene line

abnormal cytokine secretion ( J:100251 )

• mice show a decrease in the ratio of IFNG to IL-10

decreased susceptibility to autoimmune diabetes ( J:100251 )

• male and female mice expressing the transgene exhibit a significantly lower diabetes incidence compared to NOD mice; 14% of transgene-carrying females and 15% of males develop diabetes by the end of 50 weeks compared to 100% and 50% of nontransgenic female and male littermates respectively

• 3 positive glucose urine tests are indicative of diabetes

endocrine/exocrine glands

insulitis ( J:100251 )

• insulitis develops more slowly in these mice than in the other transgenic GAD transgene line

homeostasis/metabolism

abnormal urine glucose level ( J:100251 )

• three positive urine glucose tests are considered indicative of diabetes

renal/urinary system

abnormal urine glucose level ( J:100251 )

• three positive urine glucose tests are considered indicative of diabetes