All Phenotypes Thra<tm3Ven> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^tm3Ven/Thra^tm3Ven	involves: 129P2/OlaHsd * C57BL/6NCrl	MGI:3606063
ht2	Thra^tm3Ven/Thra⁺	involves: 129P2/OlaHsd * C57BL/6NCrl	MGI:3606065
ht3	Thra^tm1Ven/Thra^tm3Ven	involves: 129P2/OlaHsd * C57BL/6NCrl	MGI:3606069
ht4	Thra^tm2Ven/Thra^tm3Ven	involves: 129P2/OlaHsd * C57BL/6NCrl	MGI:3606072
cx5	Thra^tm3Ven/Thra^tm3Ven Thrb^tm1Df/Thrb^tm1Df	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl	MGI:3606074
cx6	Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl	MGI:3606079
cx7	Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb^tm1Df	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl	MGI:3606081

Allelic Composition	Thra^tm3Ven/Thra^tm3Ven
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm3Ven mutation (0 available); any Thra mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:100290 )

• homozygous mutants died within 2 weeks after birth

growth/size/body

decreased body weight ( J:100290 )

• homozygous mutants exhibited lower body weight at 10 days after birth

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:100290 )

• heterozygous mutants exhibited lower body weight at 10 days after birth and a difference increased to 33% at 30 days of age compared with wt controls

• 90-day-old heterozygous mice weighed only 7% less than wt controls

abnormal postnatal growth ( J:100290 )

• eye opening, bone ossification and development of IgM-positive B cells are delayed by 5-10 days in the juvenile mice

behavior/neurological

abnormal object recognition memory ( J:100910 )

• using the novel object recognition task to measure visual recognition memory, mutant 12-14-wk-old mice displayed a memory impairment

• administration of T3 in drinking water during adulthood restored normal recognition memory

• administration of TS during juveniles failed to correct the memory impairment

increased anxiety-related response ( J:100910 )

• 12-14-wk-old mutant mice exhibited a reduced exploratory activity in a brightly lit open field

• 12-14-wk-old mutant mice exhibited a pronounced tendency for retropulsion and a strongly increased freezing behavior

• 12-14-wk-old mutant exhibited increased anxiety-like behavior in the elevated plus maze

• administration of T3 in drinking water during adulthood abolished the abnormal exploratory activity and anxiety but not freezing behavior

• administration of T3 during P10-P35 failed to ameliorate abnormal exploratory and anxiety behaviors

abnormal locomotor coordination ( J:100910 )

• 12-14-wk-old mutant male animals had significantly reduced locomotor coordination on rotarod test

• administration of T3 and T4 during P10-P35 fully restored locomotor ability

• administration of T3 in drinking water during adulthood failed to enhance the locomotor ability

• no difference was seen between wild-type and mutant female mice

nervous system

abnormal cerebellum external granule cell layer morphology ( J:100910 )

• the mutant mice had a delay of 4-6 days in the post-natal migration of cerebellar external granular cells to the internal granular layer

• no obvious abnormalities were found among adult mutant cerebellum by histological analyses

abnormal hippocampus morphology ( J:100910 )

• mutant mice displayed a 40-50% reduction in the number of parvalbumin (PV)-positive cell bodies that was resulted from a reduction in the number of the subpopulation of GABAergic interneurons

Allelic Composition	Thra^tm1Ven/Thra^tm3Ven
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm1Ven mutation (1 available); any Thra mutation (39 available)
Thra^tm3Ven mutation (0 available); any Thra mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:100290 )

• compound heterozygous mutants exhibited 35% less body weight at 35 days of age compared with simple heterozygous Thra^tm1Ven/Thra⁺ controls

• 70-day-old heterozygous mice weighed only 16% less than simple heterozygous Thra^tm1Ven/Thra⁺ controls

abnormal postnatal growth ( J:100290 )

• delayed eye opening

Allelic Composition	Thra^tm2Ven/Thra^tm3Ven
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm2Ven mutation (1 available); any Thra mutation (39 available)
Thra^tm3Ven mutation (0 available); any Thra mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:100290 )

• compound heterozygous mutants exhibited 27% less body weight at 30 days of age compared with simple heterozygous Thra^tm2Ven/Thra⁺ controls

• 70-day-old compound heterozygous mice weighed only 5% less than simple heterozygous Thra^tm2Ven/Thra⁺ controls

Allelic Composition	Thra^tm3Ven/Thra^tm3Ven Thrb^tm1Df/Thrb^tm1Df
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm3Ven mutation (0 available); any Thra mutation (39 available)
Thrb^tm1Df mutation (1 available); any Thrb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:100290 )

• double homozygous mutant class was not found in intercross between double heterozygote Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺ indicating lethality

• actual time of death has not been determined

Allelic Composition	Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:100290 )

• male Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺ mutants exhibited 40% less body weight at 31 days of age compared with Thra⁺/Thra⁺ Thrb^tm1Df/Thrb⁺ controls

• similar results were obtained with female mice, although the growth retardation of Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺ mutants was less at 22%

abnormal postnatal growth ( J:100290 )

• the delay in eye opening was partially rescued, occurring at day 15.3 in the Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺ mutants compared with day 18.6 in the Thra⁺/Thra⁺ Thrb^tm1Df/Thrb⁺, and day 14 in the wt mice

Allelic Composition	Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb^tm1Df
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:100290 )

• male Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb^tm1Df mutants exhibited only 14% less body weight at 31 days of age compared with controls

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