Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1Ack mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Col1a1-cre)1Ack mutation
(0 available)
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skeleton
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• the number and surface of osteoclasts is reduced by 43% and 52%, respectively
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• long bones appear less radiopaque and bone mineral density is decreased
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• osteoblast number and surface are decreased by 55% and 60%, respectively and osteoid volume is decreased by 75%
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• the percentage of apoptotic osteoblasts/osteocytes is increased more than 8-fold compared to controls
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• the bone marrow space is increased with only scattered thin spicules of trabecular bone
trabecular number and thickness are decreased and trabecular separation is increased in the distal femur and proximal tibia
• however, there is no increase in bone marrow adiposity unlike Pthlh null homozygotes
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• the mineral apposition rate is decreased by 45% and 60% in the tibial cortex and trabeculae, respectively
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hematopoietic system
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• the number and surface of osteoclasts is reduced by 43% and 52%, respectively
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immune system
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• the number and surface of osteoclasts is reduced by 43% and 52%, respectively
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(Wnt7b)Flng mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Col1a1-cre)1Ack mutation
(0 available)
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skeleton
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• proximal tibial trabecular bone volume/total volume is increased 13.7 fold and 5.1 fold at 2 months and 6 months of age, respectively
• by 9 months of age bone mass of the proximal tibial trabecular area is 30% less than controls
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• osteoclast number per bone surface and percentage of bone resorption surface are reduced at 2 months of age
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• absence of a marrow space in the long bones due to complete ossification
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• profoundly dense bones in both males and females throughout the body at 2 months of age
• increased density persists at 6 months of age but is partially resolved at 9 months of age
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• by 9 months of age bone mass of the proximal tibial trabecular area is 30% less than controls
• however, bone mass remains increased in the distal tibia and femur at 9 months of age
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• proximal tibial trabecular bone volume/total volume is increased 13.7 fold and 5.1 fold at 2 months and 6 months of age, respectively
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• excessive osteoblasts in the presumptive marrow cavity at E18.5
• increased osteoblast number normalized to bone surface at 2 months of age
• however, the density of osteocytes is similar to controls
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• excessive bone occupies both primary and secondary ossification centers but the growth plate remains largely normal
• increased bone mass is seen at E18.5 and at 2 and 6 months of age
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• mineral apposition rate, the percentage of mineralizing surface, and bone formation rate are all increased in the humerus
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• increase in the serum levels of C-terminal telopeptide of type I collagen (a degradation product of type I collagen released upon bone resorption) at 1 and 9 months of age but not at 2 months of age
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homeostasis/metabolism
hematopoietic system
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• consistent with extramedullary hematopoiesis
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• osteoclast number per bone surface and percentage of bone resorption surface are reduced at 2 months of age
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immune system
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• consistent with extramedullary hematopoiesis
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• osteoclast number per bone surface and percentage of bone resorption surface are reduced at 2 months of age
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limbs/digits/tail
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• proximal tibial trabecular bone volume/total volume is increased 13.7 fold and 5.1 fold at 2 months and 6 months of age, respectively
• by 9 months of age bone mass of the proximal tibial trabecular area is 30% less than controls
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growth/size/body
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• consistent with extramedullary hematopoiesis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5(Wnt5a)Flng mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Col1a1-cre)1Ack mutation
(0 available)
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skeleton
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• do not display any obvious bone phenotype at 2 months of age
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Analysis Tools