Analysis Tools
immune system
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• transgenic mice are more susceptible to passive systemic anaphylaxis
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Allele Symbol Allele Name Allele ID |
Tg(Pim1-Il9)5Jcrd transgene insertion 5, Jean-Christophe Renauld MGI:3590500 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transgenic mice are more susceptible to passive systemic anaphylaxis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transgenic mice are highly susceptible to passive systemic anaphylaxis and die within 30 minutes of a challenge with DNP coupled to BSA 1 day after an i.v. injection with 5 ug of monoclonal anti-DP IgE, while all wild-type mice survived
• however, transgenic mice are not more susceptible to passive cutaneous anaphylaxis
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• transgenic CD4+ T cells produce more Il-5 than wild-type cells in response to anti-CD3 stimulation; secretion is inhibited by neutralization of Il-9 by addition of an antibody to the culture
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• a dose of 1 ug of N-methyl-N-nitrosourea induced tumors in all transgenic mice but did not induce tumors in wild-type mice
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• between 3 - 9 months of age, 14 of 200 transgenic mice developed tumors that appeared to arise from immature thymic T cells
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• a dose of 1 ug of N-methyl-N-nitrosourea induced tumors in all transgenic mice but did not induce tumors in wild-type mice
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• between 3 - 9 months of age, 14 of 200 transgenic mice developed tumors that appeared to arise from immature thymic T cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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