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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gad1tm1.1Tama
targeted mutation 1.1, Nobuaki Tamamaki
MGI:3590301
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gad1tm1.1Tama/Gad1+ involves: C57BL/6NCrlj * CBA/JNCrlj MGI:4941588
cx2
 		Gad1tm1.1Tama/Gad1+
Pkd2l1tm1.1Yuni/Pkd2l1tm1.1Yuni 		involves: 129S/SvEv * C57BL/6 * CBA MGI:5008624
cx3
 		Gad1tm1.1Tama/Gad1+
Pcntm239Asp/Pcntm239Asp 		involves: C57BL/6 * C57BL/6J * CBA * FVB/N MGI:4440844


Genotype
MGI:4941588
ht1
Allelic
Composition		 Gad1tm1.1Tama/Gad1+
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Tama mutation (2 available); any Gad1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:134533 )
N
• mice exhibit normal cerebellum development




Genotype
MGI:5008624
cx2
Allelic
Composition		 Gad1tm1.1Tama/Gad1+
Pkd2l1tm1.1Yuni/Pkd2l1tm1.1Yuni
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Tama mutation (2 available); any Gad1 mutation (64 available)
Pkd2l1tm1.1Yuni mutation (1 available); any Pkd2l1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nerve fiber response ( J:172581 )
• chorda tympani nerves response to sour tastants is lower than in wild-type mice

taste/olfaction
abnormal gustatory system physiology ( J:172581 )
• chorda tympani nerves response to sour tastants is lower than in wild-type mice




Genotype
MGI:4440844
cx3
Allelic
Composition		 Gad1tm1.1Tama/Gad1+
Pcntm239Asp/Pcntm239Asp
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Tama mutation (2 available); any Gad1 mutation (64 available)
Pcntm239Asp mutation (0 available); any Pcnt mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neuronal migration ( J:158418 )
• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
abnormal neuronal precursor proliferation ( J:158418 )
• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice

limbs/digits/tail

cellular
increased apoptosis ( J:158418 )
• between E10.5 and E15.5, mice exhibit increased apoptosis throughout the brain and body compared with wild-type mice
abnormal neuronal migration ( J:158418 )
• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
abnormal neuronal precursor proliferation ( J:158418 )
• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice

growth/size/body
embryonic growth retardation ( J:158418 )

embryo




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory