Analysis Tools
immune system
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• mice acutely reject skin grafts from Faslpr H2Ab-1bm12 mice similarly to wild-type mice receiving similar grafts, with no modification of graft surivival (median survival time ~14 days)
• eosinophil recruitment in skin allografts is similar to that observed in wild-type
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• increased numbers of Th1 and Th17 T cells are found in the periphery and in the CNS after experimental autoimmune encephalomyelitis compared to controls
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• regulatory FOXP3+ T cells isolated from mice with experimental autoimmune encephalomyelitis have less suppressive ability as wild-type controls
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• mice immunized with suboptimal doses of MOG peptide develop earlier and more severe disease compared to controls (mean disease onset 10.8 days versus 15.8 days, mean maximal disease score of 2.5 vs. 1.2 in controls)
• mice have increased numbers of Th1 and Th17 T cells in the CNS and in the periphery during EAE
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hematopoietic system
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• increased numbers of Th1 and Th17 T cells are found in the periphery and in the CNS after experimental autoimmune encephalomyelitis compared to controls
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• regulatory FOXP3+ T cells isolated from mice with experimental autoimmune encephalomyelitis have less suppressive ability as wild-type controls
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