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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(Wnt1/GFP)Amc
targeted mutation 2, Andrew P McMahon
MGI:3589804
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0 		involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ MGI:5305934
cn2
 		Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Tg(Hoxb7-cre)13Amc/0
Wnt9btm1.1Amc/Wnt9btm1.1Amc 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:3716215
cx3
 		Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Wnt9btm1.1Amc/Wnt9btm1.1Amc 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:3716214


Genotype
MGI:5305934
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:178316 )
N
• the cleft lip phenotype observed in Pbx1tm1.1Koss/Pbx1tm1.1Koss Pbx2tm1Mlc/Pbx2+ Tg(Tcfap2a*-cre)1Will is rescued




Genotype
MGI:3716215
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Tg(Hoxb7-cre)13Amc/0
Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:100575 )
N
• when the Wnt1:GFP fusion protein is expressed in the Wolffian duct, embryos exhibit normal mesonephric and metanephric tubule induction, as well as caudal extension of the Mullerian duct




Genotype
MGI:3716214
cx3
Allelic
Composition		 Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Wnt9btm1.1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:100575 )
• phenotype is stated to be identical to that of Wnt9btm1.1Amc homozygotes; however only limited data is presented

renal/urinary system
abnormal kidney development ( J:100575 )
• no pretubular aggregates are apparent

embryo
abnormal Mullerian duct morphology ( J:100575 )
• development is arrested




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory