All Phenotypes Ndel1<tm1.1Shr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ndel1^tm1.1Shr
targeted mutation 1.1, Shinji Hirotsune
MGI:3589465

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndel1^tm1.1Shr/Ndel1^tm1.1Shr	involves: 129S6/SvEvTac	MGI:3589747
ht2	Ndel1^tm1.1Shr/Ndel1^tm2Shr	involves: 129S6/SvEvTac	MGI:3589750
cx3	Pafah1b1^tm1Awb/Pafah1b1⁺ Ndel1^tm1.1Shr/Ndel1⁺	involves: 129S6/SvEvTac	MGI:3589752
cx4	Pafah1b1^tm2.2Awb/Pafah1b1⁺ Ndel1^tm1.1Shr/Ndel1⁺	involves: 129S6/SvEvTac	MGI:3589751

Allelic Composition	Ndel1^tm1.1Shr/Ndel1^tm1.1Shr
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndel1^tm1.1Shr mutation (0 available); any Ndel1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:100552 )

• homozygous embryos are present at E3.5 but absent at E5.5

embryo

inner cell mass degeneration ( J:100552 )

• in blastocyst cultures the inner cell mass grows poorly and degenerates shortly after 3 days in culture

Allelic Composition	Ndel1^tm1.1Shr/Ndel1^tm2Shr
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndel1^tm1.1Shr mutation (0 available); any Ndel1 mutation (40 available)
Ndel1^tm2Shr mutation (1 available); any Ndel1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:100552 )

• dendritic extensions of postmiotic neurons in the cortical plate are irregular and fragmented

abnormal hippocampus pyramidal cell morphology ( J:100552 )

• mild partial splitting and diffuse pyramidal cells are seen in the CA3 and CA2 regions of the hippocampus

Allelic Composition	Pafah1b1^tm1Awb/Pafah1b1⁺ Ndel1^tm1.1Shr/Ndel1⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndel1^tm1.1Shr mutation (0 available); any Ndel1 mutation (40 available)
Pafah1b1^tm1Awb mutation (0 available); any Pafah1b1 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:100552 )

• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone

abnormal neuronal migration ( J:100552 )

• migration defects in the hippocampus are slightly more severe than in Pafah1b1 single heterozygotes with the number of cells the reached layer II now reduced

abnormal telencephalon development ( J:100552 )

• dendritic extensions of postmiotic neurons in the cortical plate are irregular and fragmented

abnormal neocortex morphology ( J:100552 )

• a mild reduction in the number of cells in the neocortex is seen with preferential loss of later migrating cells

cellular

increased neuron apoptosis ( J:100552 )

• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone

abnormal neuronal migration ( J:100552 )

• migration defects in the hippocampus are slightly more severe than in Pafah1b1 single heterozygotes with the number of cells the reached layer II now reduced

Allelic Composition	Pafah1b1^tm2.2Awb/Pafah1b1⁺ Ndel1^tm1.1Shr/Ndel1⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndel1^tm1.1Shr mutation (0 available); any Ndel1 mutation (40 available)
Pafah1b1^tm2.2Awb mutation (0 available); any Pafah1b1 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:100552 )

• dendritic extensions of postmiotic neurons in the cortical plate are irregular and fragmented

abnormal hippocampus pyramidal cell morphology ( J:100552 )

• partial splitting of the pyramidal cells in the CA3 regions of the hippocampus is seen unlike in either single heterozygote

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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