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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck-CrmA)1Hed
transgene insertion 1, Stephen Hedrick
MGI:3588561
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Lck-CrmA)1Hed/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0 		BALB/c * C57BL/6 MGI:3588982
tg2
 		Tg(Lck-CrmA)1Hed/Tg(Lck-CrmA)1Hed involves: BALB/c * C57BL/6J MGI:3588985
tg3
 		Tg(Lck-CrmA)1Hed/0 involves: BALB/c * C57BL/6J MGI:3588983
tg4
 		Tg(Lck-CrmA)1Hed/? involves: BALB/c * C57BL/6J MGI:3588984


Genotype
MGI:3588982
cx1
Allelic
Composition		 Tg(Lck-CrmA)1Hed/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background		 BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-CrmA)1Hed mutation (0 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:100451 )
N
• HY mediated negative selection in this TCR transgenic model was not blocked or altered by the presence of Tg(Lck-CrmA)1Hed




Genotype
MGI:3588985
tg2
Allelic
Composition		 Tg(Lck-CrmA)1Hed/Tg(Lck-CrmA)1Hed
Genetic
Background		 involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:100451 )
N
• thymocyte and peripheral T cell populations were not altered




Genotype
MGI:3588983
tg3
Allelic
Composition		 Tg(Lck-CrmA)1Hed/0
Genetic
Background		 involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:100451 )
N
• thymocyte and peripheral T cell populations were not altered
decreased T cell apoptosis ( J:100451 )
• anti-CD95 induced PARP cleavage in thymocytes is blocked

cellular
decreased T cell apoptosis ( J:100451 )
• anti-CD95 induced PARP cleavage in thymocytes is blocked

hematopoietic system
decreased T cell apoptosis ( J:100451 )
• anti-CD95 induced PARP cleavage in thymocytes is blocked




Genotype
MGI:3588984
tg4
Allelic
Composition		 Tg(Lck-CrmA)1Hed/?
Genetic
Background		 involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:100451 )
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

hematopoietic system
decreased thymocyte apoptosis ( J:100451 )
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

cellular
decreased thymocyte apoptosis ( J:100451 )
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:100451 )
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory