Analysis Tools
immune system
| N |
• HY mediated negative selection in this TCR transgenic model was not blocked or altered by the presence of Tg(Lck-FADD)1Hed
|
|
Allele Symbol Allele Name Allele ID |
Tg(Lck-FADD)1Hed transgene insertion 1, Stephen Hedrick MGI:3588560 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• HY mediated negative selection in this TCR transgenic model was not blocked or altered by the presence of Tg(Lck-FADD)1Hed
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal levels of TCR surface expression
|
|
• partial block of thymocyte development at the CD25+CD44- stage of development just prior to proliferation
|
|
• T cell levels in spleen only 3% of normal levels at 3 to 4 weeks of age
|
|
• total number of thymocytes is approximately 35% that of wildtype littermates
|
|
• partial block of thymocyte development at the CD25+CD44- stage of development just prior to proliferation
|
|
• T cell levels in spleen only 3% of normal levels at 3 to 4 weeks of age
|
|
• total number of thymocytes is approximately 35% that of wildtype littermates
|
|
• total number of thymocytes is approximately 35% that of wildtype littermates
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• lymph node T cells respond almost normally to plate-bound anti-CD3 and anti-CD28 but are deficient in response to anti-CD3 and PMA or anti-CD3 and calcium ionophore
• unlike wildtype lymph node T cells or heterozygous thymocytes heterozygous lymph node T cells proliferate in response to PMA alone
|
|
• partial block of thymocytes development at the CD25+CD44- stage of development just prior to proliferation
|
|
• T cell levels in spleen only 20% of normal levels at 3 to 4 weeks of age
• CD4+ spleen and lymph node T cells increase with age to wild-type levels but CD8+ remain at low levels
|
|
• decrease in total thymocyte number
|
|
• lymph node T cells respond almost normally to plate-bound anti-CD3 and anti-CD28 but are deficient in response to anti-CD3 and PMA or anti-CD3 and calcium ionophore
• unlike wildtype lymph node T cells or heterozygous thymocytes heterozygous lymph node T cells proliferate in response to PMA alone
|
|
• partial block of thymocytes development at the CD25+CD44- stage of development just prior to proliferation
|
|
• T cell levels in spleen only 20% of normal levels at 3 to 4 weeks of age
• CD4+ spleen and lymph node T cells increase with age to wild-type levels but CD8+ remain at low levels
|
|
• decrease in total thymocyte number
|
|
• decrease in total thymocyte number
|
|
• lymph node T cells respond almost normally to plate-bound anti-CD3 and anti-CD28 but are deficient in response to anti-CD3 and PMA or anti-CD3 and calcium ionophore
• unlike wildtype lymph node T cells or heterozygous thymocytes heterozygous lymph node T cells proliferate in response to PMA alone
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no indication of lymphoproliferative disease or development of CD3+B220+ population was observed out to 1.5 years of age
|
|
• anti-CD95 plus cycloheximide fail to induce change in thymic mitochondrial potential
|
|
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis
|
|
• anti-CD95 plus cycloheximide fail to induce change in thymic mitochondrial potential
|
|
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis
|
|
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis
|
|
• CD95 induced apoptosis in thymocytes is blocked but thapsigargan, dexamethasone, and staurosporine each still induce thymocyte apoptosis
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||