Phenotypes associated with this allele

• Allele Symbol: Tmem70⁺
• Allele Name: wild type
• Allele ID: MGI:3588320
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tmem70^em2(IMPC)Bay/Tmem70^+	C57BL/6N-Tmem70^em2(IMPC)Bay/Bay	MGI:6288783
ht2	Tmem70^tm1a(KOMP)Wtsi/Tmem70^+	involves: C57BL/6N	MGI:5904754

Genotype
MGI:6288783

ht1

• Allelic Composition: Tmem70^em2(IMPC)Bay/Tmem70⁺
• Genetic Background: C57BL/6N-Tmem70^em2(IMPC)Bay/Bay

Data Sources

IMPC Data for Tmem70

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo turning ( J:211773 )

IMPC - BCM

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

Genotype
MGI:5904754

ht2

• Allelic Composition: Tmem70^{tm1a(KOMP)Wtsi}/Tmem70⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0288_2_F12

cardiovascular system

decreased heart left ventricle muscle contractility ( J:238642 )

• mild systolic dysfunction of the left ventricle (LV), as shown by a reduction in fractional shortening at 5 and 14 weeks of age

• systolic LV wall thickness is significantly decreased at 14 weeks of age

• however, heart rate and heart weight to body weight ratio is normal at both ages

muscle

decreased heart left ventricle muscle contractility ( J:238642 )

• mild systolic dysfunction of the left ventricle (LV), as shown by a reduction in fractional shortening at 5 and 14 weeks of age

• systolic LV wall thickness is significantly decreased at 14 weeks of age

• however, heart rate and heart weight to body weight ratio is normal at both ages

growth/size/body

growth/size/body region phenotype ( J:238642 )

N • normal body weight at 5 and 14 weeks of age

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:238642 )

N • normal content of assembled ATP synthase without accumulation of F1 intermediates

cellular

cellular phenotype ( J:238642 )

N • normal mitochondrial oxidative phosphorylation as determined by parameters of substrate oxidation, including State 3-ADP, State 3-FCCP, ATP production, and sensitivity to oligomycin

N • no detectable changes in mitochondrial membrane potential at State 3 or State 4