Phenotypes associated with this allele

• Allele Symbol: Pdzk1^tm1Dls
• Allele Name: targeted mutation 1, David L Silver
• Allele ID: MGI:3588076
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdzk1^tm1Dls/Pdzk1^tm1Dls	involves: 129S6/SvEvTac * C57BL/6J	MGI:3617306

Genotype
MGI:3617306

hm1

• Allelic Composition: Pdzk1^tm1Dls/Pdzk1^tm1Dls
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:107125 )

• fractional uptake rate of BSP is reduced by 25% in mutants compared with wild-type and plasma half life is increased correspondingly be 25% in knockouts

liver/biliary system

abnormal liver morphology ( J:107125 )

• scavenger receptor B, type I expression and function in mutant livers are markedly reduced in knockouts

• distribution of organic anion transporting protein 1A1 is predominantly in intracellular structures, while in wild-type it has a basolateral distribution