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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt1MommeD2
modifiers of murine metastable epiallele D2
MGI:3586549
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt1MommeD2/Dnmt1MommeD2 FVB/NJ-Dnmt1MommeD2 MGI:3607155
ht2
 		Dnmt1MommeD2/Dnmt1+ FVB/NJ-Dnmt1MommeD2 MGI:3607156
cx3
 		Avy/A
Dnmt1MommeD2/Dnmt1+ 		involves: C57BL/6J * FVB/NJ MGI:3607157


Genotype
MGI:3607155
hm1
Allelic
Composition		 Dnmt1MommeD2/Dnmt1MommeD2
Genetic
Background		 FVB/NJ-Dnmt1MommeD2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1MommeD2 mutation (0 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:99816 )
• no homozygotes are found at weaning




Genotype
MGI:3607156
ht2
Allelic
Composition		 Dnmt1MommeD2/Dnmt1+
Genetic
Background		 FVB/NJ-Dnmt1MommeD2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1MommeD2 mutation (0 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:99816 )
• about half of heterozygous females from heterozygous intercrosses do not survive to birth




Genotype
MGI:3607157
cx3
Allelic
Composition		 Avy/A
Dnmt1MommeD2/Dnmt1+
Genetic
Background		 involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (80 available); any a mutation (468 available)
Avy mutation (4 available); any a mutation (468 available)
Dnmt1MommeD2 mutation (0 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:99816 )
• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

integument
yellow coat color ( J:99816 )
• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory