All Phenotypes Smchd1<MommeD1> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smchd1^MommeD1
modifiers of murine metastable epiallele D1
MGI:3586547

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smchd1^MommeD1/Smchd1^MommeD1	FVB/NJ-Smchd1^MommeD1	MGI:3607152
hm2	Smchd1^MommeD1/Smchd1^MommeD1	involves: C57BL/6 * FVB/N	MGI:3821573
ht3	Smchd1^MommeD1/Smchd1⁺	FVB/NJ-Smchd1^MommeD1	MGI:3607151
ht4	Smchd1^MommeD1/Smchd1⁺	involves: C57BL/6 * FVB/N	MGI:3821572
ht5	Smchd1^{Gt(AD0165)Wtsi}/Smchd1^MommeD1	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3821574
cx6	A^vy/A Smchd1^MommeD1/Smchd1⁺	involves: C57BL/6J * FVB/NJ	MGI:3607153

Allelic Composition	Smchd1^MommeD1/Smchd1^MommeD1
Genetic Background	FVB/NJ-Smchd1^MommeD1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:99816 )

• female homozygotes die between E10.5 and E14.5, but male homozygotes are viable

cellular

abnormal imprinting ( J:99816 )

• no DNA methylation is detected at the CpG island of Hprt

Allelic Composition	Smchd1^MommeD1/Smchd1^MommeD1
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal maternal decidual layer morphology ( J:142334 )

• decidua of female embryos smaller at E9.5 and E10.5

abnormal trophoblast layer morphology ( J:142334 )

• smaller trophoblast giant cell layer in females

abnormal trophoblast giant cell morphology ( J:142334 )

• nuclei of trophoblast giant cells are markedly smaller than controls

cellular

abnormal DNA methylation ( J:142334 )

• hypomethylation of CpG islands in genes subject to X-inactivation

reproductive system

abnormal maternal decidual layer morphology ( J:142334 )

• decidua of female embryos smaller at E9.5 and E10.5

Allelic Composition	Smchd1^MommeD1/Smchd1⁺
Genetic Background	FVB/NJ-Smchd1^MommeD1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:99816 )

• DNA methylation is decreased at the CpG island of Hprt

Allelic Composition	Smchd1^MommeD1/Smchd1⁺
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:142334 )

• heterozygous female methylation levels are low in embryos but become normal in adults

Allelic Composition	Smchd1^{Gt(AD0165)Wtsi}/Smchd1^MommeD1
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smchd1^{Gt(AD0165)Wtsi} mutation (0 available); any Smchd1 mutation (143 available)
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:142334 )

• no females found at birth

Allelic Composition	A^vy/A Smchd1^MommeD1/Smchd1⁺
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

integument

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23