Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gata1-Zfpm1)1Sho mutation
(0 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
Zfpm1tm4Sho mutation
(0 available);
any
Zfpm1 mutation
(31 available)
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cardiovascular system
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• variably thinner than wild type but not as thin as that seen in the Zfpm1 knockout embryos
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• observe a small degree of conal rotation, resulting in a slightly more rostral origin of the aorta from the right ventricle compared with that of the pulmonary artery
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• have a single common atrioventricular valve
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muscle
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• variably thinner than wild type but not as thin as that seen in the Zfpm1 knockout embryos
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gata1-Zfpm1)1Sho mutation
(0 available)
Zfpm1tm1Sho mutation
(0 available);
any
Zfpm1 mutation
(31 available)
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Cardiac defects in Zfpm1tm1Sho/Zfpm1tm1Sho Tg(Gata1-Zfpm1)1Sho mice
mortality/aging
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• with transgene rescue, embryos die between E14.5 and E15.5 with normal appearing primitive blood cells in the yolk sac and fetal liver
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hematopoietic system
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N |
• hematopoiesis, definitive erythropoiesis and megakaryopoiesis defects seen in homozygous Zfpm1 mice are rescued by the transgene
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cardiovascular system
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• myocardium is variably thinner than wild-type but not as thin as in homozygous Zfpm2tm1Sho mice
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• have a single common atrioventricular valve
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• atrioventricular canal defect
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homeostasis/metabolism
integument
muscle
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• myocardium is variably thinner than wild-type but not as thin as in homozygous Zfpm2tm1Sho mice
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Analysis Tools