Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppiftm1Maf mutation
(1 available);
any
Ppif mutation
(18 available)
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cellular
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• basal, ADP- and uncoupler-stimulated rates of respiration are normal but sensitivity to calcium induced permeability transition is reduced and mitochondria are insensitive to cyclosporin A-induced swelling
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppiftm1Maf mutation
(1 available);
any
Ppif mutation
(18 available)
Tg(THY1-SNCA*A53T)M53Sud mutation
(1 available)
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mortality/aging
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• although mice start to die around 36 weeks of age and all die by 60 weeks of age, survival is extended compared to single Tg(THY1-SNCA*A53T)M53Sud transgenic mice
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nervous system
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• mice exhibit a delay in disease onset compared to single (THY1-SNCA*A53T)M53Sud transgenic mice
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Analysis Tools