Phenotypes associated with this allele

• Allele Symbol: Sstr5^tm2Fcb
• Allele Name: targeted mutation 2, F Charles Brunicardi
• Allele ID: MGI:3584184
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sstr5^tm1Fcb/Sstr5^tm2Fcb Tg(Ins2-cre)1Heed/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3603657

Genotype
MGI:3603657

cn1

• Allelic Composition: Sstr5^tm1Fcb/Sstr5^tm2Fcb; Tg(Ins2-cre)1Heed/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic delta cell number ( J:99786 )

• the number of somatostatin+ delta cells is decreased to 7% and 3% of the islets cells in female and male homozygotes, respectively, compared to 13% and 9% in female and male wild-type mice

decreased insulin secretion ( J:99786 )

• when islets are incubated in vitro in a high glucose solution levels of glucose-stimulated insulin secretion are significantly decreased

• at 3 months of age 15 minutes after an injection of glucose insulin levels are not increased unlike in control mice

increased insulin secretion ( J:99786 )

• serum C-peptide levels are increased at 3 and 12 months of age suggesting an increase in beta cell insulin release

homeostasis/metabolism

decreased insulin secretion ( J:99786 )

• when islets are incubated in vitro in a high glucose solution levels of glucose-stimulated insulin secretion are significantly decreased

• at 3 months of age 15 minutes after an injection of glucose insulin levels are not increased unlike in control mice

increased insulin secretion ( J:99786 )

• serum C-peptide levels are increased at 3 and 12 months of age suggesting an increase in beta cell insulin release

decreased circulating glucose level ( J:99786 )

• at 12 months but not at 3 months of age, fasting blood glucose levels are decreased

increased circulating insulin level ( J:99786 )

• at 12 months but not at 3 months of age, basal insulin levels are increased

impaired glucose tolerance ( J:99786 )

• at 12 months but not at 3 months of age, the increase in serum glucose levels is much greater and the increase in serum insulin levels is decreased compared to wild-type mice

abnormal insulin clearance ( J:99786 )

• at 3 months of age after insulin injection blood glucose and insulin levels return to normal levels sooner than in control mice