Phenotypes associated with this allele

• Allele Symbol: Rspo2⁺
• Allele Name: wild type
• Allele ID: MGI:3584152
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rspo2^tm1Nuv/Rspo2^+	involves: 129 * C57BL/6	MGI:3762380
ht2	Rspo2^ftls/Rspo2^+	involves: FVB/N	MGI:3045981

Genotype
MGI:3762380

ht1

• Allelic Composition: Rspo2^tm1Nuv/Rspo2⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:126341 )

♀ • females but not males show reduced fertility with age (25% sterile at 4 months and 85% sterile after 5 months of age)

Genotype
MGI:3045981

ht2

• Allelic Composition: Rspo2^ftls/Rspo2⁺
• Genetic Background: involves: FVB/N

craniofacial

cleft secondary palate ( J:83881 )

• observed in 2 of 125 fetuses

endocrine/exocrine glands

ovary cyst ( J:83881 )

♀ • observed in some females

renal/urinary system

delayed kidney development ( J:83881 )

• bilateral supernumerary kidneys observed in some fetuses

single kidney ( J:83881 )

• unilateral absence in some fetuses

reproductive system

ovary cyst ( J:83881 )

♀ • observed in some females

decreased ovulation rate ( J:83881 )

♀ • decreased ovulation rates, possibly due to diminished hormonal responsiveness or ovarian cysts

reduced female fertility ( J:83881 )

♀ • females were found to be fertile until ~4 months of age

digestive/alimentary system

cleft secondary palate ( J:83881 )

• observed in 2 of 125 fetuses

growth/size/body

cleft secondary palate ( J:83881 )

• observed in 2 of 125 fetuses

ovary cyst ( J:83881 )

♀ • observed in some females