Phenotypes associated with this allele

• Allele Symbol: Tg(UAS-IHH)1Amc
• Allele Name: transgene insertion 1, Andrew P McMahon
• Allele ID: MGI:3584022
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pthlh^tm1Hmk/Pthlh^+ Tg(Col2a1-GAL4)1Amc/0 Tg(UAS-IHH)1Amc/0	involves: 129S2/SvPas * C57BL/6	MGI:3584341
cx2	Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-GAL4)1Amc/0 Tg(Col2a1-PTHR1*H223R)AHju/? Tg(UAS-IHH)1Amc/0	involves: 129S2/SvPas * C57BL/6	MGI:3584352
cx3	Tg(Col2a1-GAL4)1Amc/0 Tg(UAS-IHH)1Amc/0	involves: C57BL/6	MGI:3584279
cx4	Tg(Col2a1-GAL4)1Amc/0 Tg(UAS-IHH)1Amc/0	Not Specified	MGI:3584117

Genotype
MGI:3584341

cx1

• Allelic Composition: Pthlh^tm1Hmk/Pthlh⁺; Tg(Col2a1-GAL4)1Amc/0; Tg(UAS-IHH)1Amc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased long bone epiphyseal plate size ( J:99641 )

• growth plate is shorted by about 8%

Genotype
MGI:3584352

cx2

• Allelic Composition: Pthlh^tm1Hmk/Pthlh^tm1Hmk; Tg(Col2a1-GAL4)1Amc/0; Tg(Col2a1-PTHR1*H223R)AHju/?; Tg(UAS-IHH)1Amc/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6

skeleton

abnormal long bone epiphyseal plate morphology ( J:99641 )

• increase in length of the columnar region compared to Pthlh mutant mice that express the constitutively active PTHR1 but do not overexpress IHH

Genotype
MGI:3584279

cx3

• Allelic Composition: Tg(Col2a1-GAL4)1Amc/0; Tg(UAS-IHH)1Amc/0
• Genetic Background: involves: C57BL/6

skeleton

absent neurocranium ( J:99641 )

increased long bone epiphyseal plate size ( J:99641 )

• longitudinal expansion of the growth plate of E17.5 distal tibia

abnormal chondrocyte morphology ( J:99641 )

• increased proliferation of periarticular chondrocytes despite a decrease in the number of periarticular chondrocytes, indicating acceleration of periarticular chondrocyte differentiation

• increase in the number of columnar chondrocytes, however no difference in the proliferation rate of columnar chondrocytes

decreased chondrocyte number ( J:99641 )

• decrease in the number of periarticular chondrocytes

fused joints ( J:99641 )

• fusion of knee joints

craniofacial

absent neurocranium ( J:99641 )

abnormal facial morphology ( J:99641 )

• exhibit facial malformations

growth/size/body

abnormal facial morphology ( J:99641 )

• exhibit facial malformations

Genotype
MGI:3584117

cx4

• Allelic Composition: Tg(Col2a1-GAL4)1Amc/0; Tg(UAS-IHH)1Amc/0
• Genetic Background: Not Specified

skeleton

abnormal long bone epiphyseal plate proliferative zone ( J:73071 )

• 20% increase in chondrocyte proliferation at E14.5 and 60% increase at E16.5 in the proliferative zone of the tibia, mainly in the region close to the articular surface of the cartilage