Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo2tm3Thr mutation
(0 available);
any
Lmo2 mutation
(31 available)
Lmo2tm4Thr mutation
(0 available);
any
Lmo2 mutation
(31 available)
Tg(Lck-cre)1Thr mutation
(0 available)
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hematopoietic system
N |
• mutant mice are viable and exhibit no hematopoietic defects, with normal bone marrow, spleen and thymus cell counts
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immune system
N |
• normal T and B lymphoid development
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Thr mutation
(0 available);
any
Kmt2a mutation
(135 available)
Mllt3tm2Thr mutation
(0 available);
any
Mllt3 mutation
(31 available)
Tg(Lck-cre)1Thr mutation
(0 available)
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neoplasm
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• 18 of 20 mice develop hematopoeitic neoplasm that are either T cell or myeloid in origin
• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes
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• mice develop small T cell lymphomas
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• mice have myelo-proliferative-like myeloid leukemia without circulating leukemic cells
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hematopoietic system
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• splenomeglia is caused by a repopulation of the spleen with malignant cells
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• red and white pulp architecture is lost
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• red and white pulp architecture is lost
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immune system
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• splenomeglia is caused by a repopulation of the spleen with malignant cells
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• red and white pulp architecture is lost
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• red and white pulp architecture is lost
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growth/size/body
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• splenomeglia is caused by a repopulation of the spleen with malignant cells
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endocrine/exocrine glands
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• mice develop small T cell lymphomas
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Thr mutation
(0 available);
any
Kmt2a mutation
(135 available)
Mllt1tm1Thr mutation
(0 available);
any
Mllt1 mutation
(21 available)
Tg(Lck-cre)1Thr mutation
(0 available)
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neoplasm
N |
• no hematological malignancies are observed
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